The present invention provides a method for ranking patients based on a scoring rate derived from imaging-based data, where the data includes information on fat, plaques, and/or other physiologically image-discernible structures (vasa vasorum, other micro-vascularizations, etc.) and where the scoring rate ranks patients with respect to their vulnerability to cardiovascular events such as heart attacks, strokes or other similar cardiovascular events.

A method for identifying an individual includes the steps of collecting data from an individual’s face using visible and infrared cameras, processing the acquired data, fitting a geometric model template of the face to the data according to a mathematical method, processing the fitted model to extract relevant first metadata, storing the first metadata in a machine readable format, and comparing second metadata to the first metadata, to determine their degree of similarity in order to identify the individual.

Magnetoencephalography (MEG) and functional Magnetic Resonance (fMR) data are as useful as their understanding by physicians. A methodology and associated software for the 3D co-registration and manipulation of functional brain data within a standard anatomical brain as well as animated display of their time- or condition-related behavior significantly enhances their information value and allows comparisons across stimuli, subjects and modalities.

This invention provides a practical method for grafting OEG or PEG directly on hydrogen-terminated silicon surfaces. It also allows for photo-patterning the silicon surfaces.

This invention uses several engineering improvements in electrophoresis techniques including a novel end-column detection method so that any charged biological molecules (especially DNA or RNA) are eluted from the column into free solution for direct precipitation. The invention minimizes the elution reservoir volume for efficient precipitation while still controlling the pH.

The present invention relates to the use of adsorbents to enhance binding affinity, or enhanced selectivity for protein separation and isolation. This invention particularly relates to the hypothesis that clustering of charges on ion exchangers might enhance binding affinity or enhance selectivity for proteins displaying charge clusters on their surfaces. This technology may be useful in improving ion exchange capacity and specificity for target biomolecules and may be extended to improve affinity chromatography by clustering affinity ligands.

Novel protein probes may also be prepared for toxic metals, ions, molecules, cytokines, carcinogen viral, bacterial or any other pathogen. All of these proteins will be plated onto a specialized microscope slide attached to the surface using protein array technology. The fluorescence can be studied without any reagents. The results can be compared with the positive controls and be processed by SAS statistical technology to interpret the findings into a proper diagnostics relevance. In most cases the results of each type of microarray slides will be stored in a positive control database built in the computer and will be available instantaneously to the user. This facilities can be employed all the pharmacies in developed world and anyone who can afford to have a computer such as PC, laptop, palm top, or any mode of communications.

1)It will vastly improve the detection sensitivity (down to a single molecule). This, for example, allows for detection of protein variations correlated with diseases, which are expressed at very low lever.

2) Single molecule arrays will greatly facilitate single molecule sequencing of DNA using polymerase and nucleotides that are fluorescently labeled. Single molecule arrays of the template and the polymerase will reduce the background fluorescence and greatly improve the quality of the data.

Nanometric arrays will become a powerful research tool for studying the cooperative interaction among multiple biomolecules.

The present disclosure addresses certain deficiencies in the art by providing a system in which a user is able to interactively design a custom microarray that is fabricated quickly and inexpensively. A comprehensive probe database contains designed probes (virtual probes) and the performance markers of these probes. A user is able to access the database to select sequence probes for many organisms and to select particular families of genes based on function, location, or other criteria in order to construct a completely customer array containing physical probes.

The present invention relates to treatment of eye diseases by using hydrogen sulfide (H2S). This invention is a simple method that reduces the intraocular pressure in the eye as a treatment of diseases such as glaucoma. Glaucoma is a blinding disease of the eye that affects three million people in the United States, with more than 120,000 blind due to this condition.

Our discovery will allow the manufacture of small protein particles and clusters for various applications. We propose a method for the production of protein solution droplets of volume of ~100 attoliters (10^-16 liters). The method is based on liquid-liquid separation in protein solution. This can be achieved with any protein if polyethylene glycol and electrolytes such as NaCl or NH4SO4 are added to the protein solution. The droplets are generated by nucleation in solution of low super saturation with respect to the dense liquid phase. Their growth is stopped at the desired size of 0.5-1.0 mm.

Before clinical investigations in humans, various in-vitro (e.g. hollow-fiber) and animal infection models are often used to demonstrate antimicrobial activity of new compounds. However, initial choice of dosing regimens to be tested is often empiric (mostly trial and error). Pharmacodynamic modeling can be used as a decision support tool to facilitate rational dosage design. It emphasizes the fact that effective antimicrobial treatment is attributed to neither antimicrobial agent exposure nor pathogen susceptibility alone, but rather a complex interplay of both factors. Mathematical modeling and computer simulation of microbial response to antimicrobial agents hold great promise in accelerating/improving the development of antimicrobial agents. They have the capability to perform comprehensive screening of a large number of agent candidates to guide highly targeted testing. Only promising agents and dosing regimens with high probability of success would be subsequently investigated in (pre-) clinical studies. Investigations of agents predicted to have limited clinical utility would be abandoned, avoiding unnecessary use of resources. Consequently, the efficiency and cost-effectiveness of drug development will be enhanced.

The invention covers the creation and use of nanocomposite adsorbent materials comprising nanoporous zirconium oxides or titanium oxides in combination with manganese oxides for the oxidation and adsorption of arsenite, As (III), and arsenate, As (V), from drinking water. These materials are superior to the materials now in the marketplace.

The present invention relates to an in vitro enzymatic approach for the design of proteins containing unnatural amino acids where the inactivation of the editing active site using mutants of leucyl-tRNA synthetase allows amino acids other than the cognate leucine to be aminoacylated to tRNA. The resulting misaminoacylated tRNAs can be incorporated into in vitro or in vivo translation systems to incorporate non-standard or novel amino acids at specific sites within custom design proteins.

The rapidly growing fields of nanoscience and technology, single molecule studies, and biological research in academia and industries have accelerated the growth of the SPM and probe tip markets, and has called for the development of advanced technology for production of high performance tips. This invention targets a novel way of improving AFM tip resolution by modifying AFM probe tips using a chip-based technology

First level - a practical method for parallel modification of a large number (over thousands) of silicon SPM tips with a rapid, robust, ultra-thin layer of organic molecules, without substantially enlarging the tip size. The radii of the apex of these tips remain in the range of 5-20 nm upon modification.

Second and third levels - a chip-based technology. This technology is not only for tip manufactures to produce "routine" types of modified tips, but also for normal SPM users to prepare their own, highly specified tips using the chips that are produced in large scale by the manufactures. The preparation of single molecule tips with these chips is rapid, and the modified tips can be evaluated in situ using the same chip and thus ensure the quality of the tips. The chips contain many different functional molecules, and can be reused many times, thus lowering the cost. A method for replacing photo-bleached fluorescent dyes is also included.
Working prototypes for tip modification at all three levels have been obtained.
Patent Status: Pending
Availability: Available for exclusive/non-exclusive licensing
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